Effectiveness of various regimens of systemic anti-inflammatory therapy with glucocorticoids in the development of acute LPS-induced lung damage in the experiment

BACKGROUND: When studying new and effective methods of treating acute respiratory distress syndrome, an immunogenic model lung injury occupies a special place. To date, the search for optimal strategy regimen use glucocorticoids in development syndromе is relevant.
 AIM: The article evaluates effectiveness various schemes systemic anti-inflammatory therapy with experimental LPS-induced injury.
 MATERIALS AND METHODS: study was conducted on 100 outbred male rats. Acute modeled using direct by single intratracheal injection lipopolysaccharide (LPS) from cell wall bacterium Salmonella enterica (Sigma-Aldrich) at dose LD50 (20 mg/kg). All animals were divided into groups each): 1 intact rats; 2 control group (LPS + saline); 3 LPS dexamethasone 0.52 mg/kg (small doses); 4 1.71 (average 5 8 (high doses). drugs administered intraperitoneally once day days. Dexamethasone doses calculated interspecies transfer method factor that takes account differences body surface area.
 RESULTS: It has been established based endotracheal administration S. leads to mortality pulmonary causes. According preclinical study, low (0.52 mg/kg) found be better than higher (1.71 mg/kg, treatment injury.